June 27, 2016

Sublingual Immunotherapy

Sublingual Immunotheraphy


  • A very safe treatment that uses the patient’s own immune system to achieve results. The immune system is introduced to the allergen in small and increasing doses until natural immunity is developed.
  • Currently considered off-label by the FDA, but uses the same safe and FDA-approved extracts used in traditional subcutaneous immunotherapy (allergy shots).
  • Allergy symptoms may potentially begin to subside as early as 1-3 months following the beginning of treatment. Most patients notice an improvement within 6-12 months. Full treatment ranges between 3-4 years and can last many years, if not a lifetime.
  • Drops are placed under the tongue and can be taken at home
  • Drops are administered on a daily basis
  • Estimated cost including office visits, testing and drops is $4800
  • Is a travel friendly treatment option
  • Side effects are mild and include stomach aches, irritation under the tongue, or an increase in allergy symptoms
  • Most patient do not experience side effects


  • A safe, FDA approved treatment that uses the patient’s own immune system to achieve results. The immune system is introduced to the allergen in small and increasing doses until natural immunity is developed.
  • Allergy symptoms may subside as early as 3-6 months following the start of treatment. Full recovery takes approximately 3-4 years and can last many years, if not a lifetime
  • Shots are administered in office by a highly-trained Allergist. Patients are monitored for 30 minutes following treatment to establish that there is no reaction.
  • In the first several courses of treatment, injections are administered 1-2 times per week, then gradually tapered depending on the patient’s particular response and needs.
  • Estimated cost including office visits, testing and 4 years of therapy shots is $6800-$8400
  • Shots must be administered at the office
  • Side effects are usually mild, but can be moderate or severe in some patients, even leading to discontinuation of therapy.

The allergy specialists at Peak ENT are committed to providing collaborative, comprehensive care on an individual basis. Working in conjunction with the patient, our team of health care specialists provide in depth, modern health care for the well-being of the patient and their families.

Does my health insurance cover SLIT?

Insurance does typically cover all or some portion of allergy testing.

However, most insurance plans do not pay for allergy drops at this time. Call your insurance company to discuss your benefits. Even though the drops are paid for out-of-pocket, there is still substantial cost savings with allergy drops compared to allergy shots. Because fewer office visits are required with allergy drops, you can expect significant cost savings on insurance co-pays, missed work and costs for travel time for clinic visits.

What are the potential side effects from SLIT?

Thankfully, side-effects from allergy drops are rare.   Most of our patients report no side effects at all.  However, sometimes the following mild reactions occur:

  • Mild increase in allergy symptoms
  • Stomach ache
  • Irritation under the tongue

These symptoms usually go away within thirty minutes after the drops are taken.  All side-effects usually completely resolve within 1 week of starting the drops.  If side effects seem more severe or last longer than 2 weeks, please contact our office right away.  In the unlikely event that you have a severe reaction, call 911 or go to the nearest hospital emergency room right away.

What are the benefits of SLIT, and when will I start to notice improvement?

Often, symptoms decrease within a few weeks after starting allergy drops.  However, it may take up to one year before you begin to notice improvement.   Our goal is at least an 80% reduction in symptoms.  Some patients experience 100% allergy relief, but most still experience some allergy symptoms that are less intense than before treatment.

You can take your allergy drops in the privacy of your home.  Compared to allergy shots, you do not have to worry about travel expenses or the cost of missed work/school/childcare due to frequent office visit requirements.  Once stable on your drops, you can sign up for auto-refill to receive your drops every 3 months by mail.   Once the 3-4 year treatment course is completed, you can expect long-term, even life-long reduction of your allergy symptoms.

How is SLIT Provided?

Your personal prescription for immunotherapy is prepared based on your unique allergy test results.  Allergen extracts are prepared in our office by mixing them with a glycerin-saline solution.  Drops are placed under the tongue daily.  The concentration of allergen extracts is gradually increased every 3-4 weeks with a new bottle until you reach your maintenance dose.  The drops contain no phenol or other toxins.

Can I take allergy medications while I’m taking SLIT drops?

Yes!  Allergy medications do not interfere with allergy drops.  In fact, allergy medications are often used in the early stages of allergy drops.  However, your need for allergy medications should decrease during the course of your treatment.

Can children use SLIT?

Yes!   Allergy drops are safe and effective for children.  They will appreciate not needing a shot, too!

How do I know if I am a candidate for SLIT therapy?

Allergy testing (skin prick testing and/or blood tests) is the first step to determine what you’re allergic to.  Since both types of immunotherapy are effective, the decision between SLIT (drops) and SCIT (shots) often comes down to a question of safety, cost, and convenience.   Our staff and providers are happy to counsel you to decide what is right for you and your family.

Allergy Questionnaire
Allergy Drops Patient Info Sheet
Allergy Test Instruction Sheet
Allergy Testing Consent Form
AAOA Protocol Instructions